i CYTOGENETIC ANDMOLECULAR GENETIC STUDIES OF CHILDREN WITH DOWN SYNDROME AND ASSOCIATED RISK FACTORS IN KANO STATE, NIGERIA
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Date
2021-05-26
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Ahmadu Bello University Zaria
Abstract
Down syndrome (DS) is the most common type of chromosomal trisomy found in the newborn.
It is associated with hypotonia, delayed development, mental retardation and characteristic facial
features.This study of cytogenetic analysis was conducted toconfirm the clinical diagnosis of
Down syndrome (DS)and to evaluate the risk factors associated with trisomy 21 in a group of
subjects in Kano State of Nigeria.The study alsodemonstrate sensitivity of DNA diagnosis of
Down syndrome using polymerase chain reaction (PCR) and short tandem repeat (STR) markers,
and to determine the origin of the non-disjoined chromosome 21.