ANTI-DIABETIC STUDIES OF Chromolena odrata FLAVONOID FRACTION IN STREPTOZOCIN-TREATED RATS: INVOLVEMENT OF TGR5/INSULIN/PDX 1 PATHWAY
| dc.contributor.author | Ojochenemi Aladi ENEJOH | en |
| dc.creator | Ojochenemi Aladi ENEJOH | en |
| dc.date.accessioned | 2023-09-22T20:09:26Z | |
| dc.date.available | 2023-09-22T20:09:26Z | |
| dc.date.issued | 2021-11-11 | en |
| dc.description.abstract | The results showed that CoF up-regulated the expression of insulin and pancreatic duodenal homeobox-1 genes in the pancreas, and GLP-1 in the intestine. In the kidney, BUN/SC levels were restored to pre-STZ treatment states following CoF treatment. Inflammatory and kidney injury molecule -1 genes were equally significantly down-regulated (p<0.05) in STZ-CoF treated group in comparison with STZ-only group. In the aorta, the significant increase of inflammatory genes as a result of STZ treatment, were down-regulated by CoF intervention. CoF also significantly increased antioxidant genes that were down-regulated in the STZ-only group. Histo-structural alterations associated with STZ treatment were completely reversed in STZ-CoF group in the pancreas, kidney and aorta. NOAEL experiments revealed that CoF is relatively safe up to doses of 100 mg/kg b.w. Moleculardynamics simulation confirmed TGR5 as the putative target, where it evolved active state conformation from a starting intermediate state conformation when bound to CoF. Further studies revealed that the performance ofCoF was highly comparable with metformin (an anti-diabetic drug). | en |
| dc.identifier.uri | https://teras.ng/api/asset/document/ef8e6c31-2134-4d02-91fa-c23da62e6ce1 | en |
| dc.identifier.uri | https://teras.ng/catalog-item/9c17f7a1-6554-41b7-94d7-375366534865 | en |
| dc.identifier.uri | http://dspace.teras-network.net:4000/handle/123456789/43182 | |
| dc.publisher | Adekunle Ajasin University Akungba | en |
| dc.title | ANTI-DIABETIC STUDIES OF Chromolena odrata FLAVONOID FRACTION IN STREPTOZOCIN-TREATED RATS: INVOLVEMENT OF TGR5/INSULIN/PDX 1 PATHWAY | en |
| dc.type | Undergraduate Theses | en |
| thesis.degree.level | Bachelors | en |
| thesis.matric.number | 169418002 | en |