CONTROLLED RELEASE FORMULATIONS OF ANTIRETROVIRAL (ARV) DRUGS USING POLYMETHACRYLATE POLYMERS
| dc.contributor.author | MAHMUD SANI-GWARZO | en |
| dc.creator | MAHMUD SANI-GWARZO | en |
| dc.date.accessioned | 2023-09-22T21:00:34Z | |
| dc.date.available | 2023-09-22T21:00:34Z | |
| dc.date.issued | 2010-09-27 | en |
| dc.description.abstract | To improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelfinavir, nevirapine, stavudine and zidovudine) and their clinically approved combinations were used in this study. Calculated daily dose was divided into one loading and four maintainace doses. Granules of the drugs, prepared using wet granulation method, were divided into five batches and spray coated with various grades of polymethacrylate polymers (Eudragit brand). Using different combinations/ratios, each ARV drug and their combinations were filled into capsules of sizes 00 to 000. Parameters such as solubility, disintegration, coating thickness and dissolution were determined. In- vitro testing for drug release was conducted to mimic various pH conditions of the G.I.T using disodium hydrogen orthophosphate and potassium dihydrogen phosphate buffers. Spectrophotometric method was used to determine drug release. To serve as control, conventional forms of the seven ARVs obtained from a major manufacturer were tested for drug release | en |
| dc.identifier.uri | https://teras.ng/api/asset/document/13c45250-c27a-4319-a17e-542b477705fd | en |
| dc.identifier.uri | https://teras.ng/catalog-item/9d7c0d7b-f75c-44b4-8ad0-8974008eaf36 | en |
| dc.identifier.uri | http://dspace.teras-network.net:4000/handle/123456789/44199 | |
| dc.publisher | Ahmadu Bello University Zaria | en |
| dc.title | CONTROLLED RELEASE FORMULATIONS OF ANTIRETROVIRAL (ARV) DRUGS USING POLYMETHACRYLATE POLYMERS | en |
| dc.type | Research Theses | en |
| thesis.degree.level | Phd | en |
| thesis.matric.number | PhD / PHARM. SCI. / 30441 / 2001-02 | en |