KIDNEY FUNCTION STATUS OF PATIENTS ATTENDING NATIONAL ORTHOPAEDIC HOSPITAL DALA-KANO, NIGERIA
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Date
2016-12-01
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Bayero University Kano
Abstract
Kidney dysfunction in orthopaedic cases may be as a result of kidney injury due
to fracture, burns, osteomyelitis, spinal injury, spinal tuberculosis, sickle cell
disease and various forms of arthritis among others. This study was aimed at
assessing the biomarkers kidney of dysfunction among patients attending
National Othropeadic Hospital, Dala Kano. It is prospective randomized study
conducted on total of one hundred (100) subjects; sixty (60) patients and forty
(40) apparently healthy individuals between the ages of 20-80 years among both
sexes. Serum urea, creatinine, malondialdehyde, uric acid, calcium, phosphate
and chloride concentrations were estimated by spectrophotometric methods;
sodium and potassium concentration by flame photometric method; bicarbonate
by titrimetric method while eGFR and BMI were calculated. The number of
males 43(71.7%) were more than females 17(28.3%) among which students
were 18(30%), civil servants 12(20%), business 11(18.3%), housewives
9(15%), engineers 1(1.7%) while the rest of occupations were 9(15%) among
the patients respectively. Overall prevalence of kidney disease in this study was
1.7% which is higher in males (2.3%) than their female counterparts (0%).
Kidney disease was found among gouty arthritis patients within the age group
61-80 years, however none was found among 20-40 and 41-60 years. There was
significant difference (p<0.05) in mean serum potassium (4.0±04 and 3.8±0.4
mmol/l), eGFR (188±54 and 152±33 ml/min/1.73m2
) and BMI (21.28±4.4 and
25.48±5.6 kg/m2
) between males and females respectively. The prevalence of
kidney dysfunction in orthopaedic patients was higher in males than females
and increasing with age and related to underweight. However, most of the
biomarkers of kidney function are irrespective of gender.