EVALUATION OF ANTI-INFLAMMATORY EFFECTS OF AQUEOUS LEAF EXTRACT OF SYZYGIUM GUINEENSE ON CARRAGEENAN-INDUCED PAW OEDEMA IN ADULT MALE WISTAR RATS
| dc.contributor.author | Abbas IBRAHIM, | en |
| dc.creator | Abbas IBRAHIM, | en |
| dc.date.accessioned | 2023-09-21T18:02:08Z | |
| dc.date.available | 2023-09-21T18:02:08Z | |
| dc.date.issued | 2021-07-27 | en |
| dc.description.abstract | Inflammation is implicated in many disease conditions, such as cardiovascular diseases, diabetes mellitus and cancer. Syzygiumguineensehas been reported to contain active phytochemicals that may inhibit the inflammatory responses, decrease the levels of inflammatory mediators and attenuate the abnormal formation of reactive oxygen metabolites. The aim of this study is to determine the Anti-Inflammatory Effects of Aqueous Leaf Extract of Syzygiumguineenseon Carrageenan-induced Paw Oedema inAdult Male Wistar Rats.At the beginning of the study acute toxicity studies was carried out, which showed that the aqueous leaf extract of Syzygium guineense is safe to use since no mortality was recorded and no signs of toxicity was developed by the animals in each phases of acute toxcity studies. The preliminary phytochemical analysis was also conducted and variuos active agents were present in aqueous leaf extract of Syzygium.Thirty albino wistar rats were used for the study, the animals were divided into six (6) groups of five (5) rats each. The animals were grouped as follows: Group I received normal saline 1mg/kg only. Group II receive carrageenan injection only. Group III wasadministered with Diclofenac 10mg/kg orally. Group IV receieved 250mg/kg, Group V received 500mg/kg, and Group VI received 1000mg/kg ofSyzygiumguineense per orally. One hour after the administrations, each rat except group I, was injected with 0.1ml of carragenan (1%w/v) into the subplanter region of the right hind paw. All the three doses of aqueous leaf extract of Syzygiumguineense, and Diclofenac 10mg/kgsignificantly (P≤0.05) inhibited the Carrageenan induced paw oedema after 3 hours. The anti-oxidant enzymes, SOD,CAT and GSH levels were not significantly (P≤0.05) increased bySyzygiumguineensecompared to carrageenan group, but the 250mg/kg dose increase the SOD and CAT levels compared to normal saline group. The 250mg/kg ofSyzygium guineense caused statistically significant (P≤0.05) increase in Neutrophil countscompared Carrageenan and normal | en |
| dc.identifier.uri | https://teras.ng/api/asset/document/0a0fe49c-8de0-4d7e-a374-08386c18f334 | en |
| dc.identifier.uri | https://teras.ng/catalog-item/b8f1913d-72ba-4ba2-a8ed-6cae302f31ec | en |
| dc.identifier.uri | http://dspace.teras-network.net:4000/handle/123456789/11270 | |
| dc.publisher | Ahmadu Bello University Zaria | en |
| dc.title | EVALUATION OF ANTI-INFLAMMATORY EFFECTS OF AQUEOUS LEAF EXTRACT OF SYZYGIUM GUINEENSE ON CARRAGEENAN-INDUCED PAW OEDEMA IN ADULT MALE WISTAR RATS | en |
| dc.type | Research Theses | en |
| thesis.degree.level | Masters | en |
| thesis.matric.number | P15MDHP8013 | en |