COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN
| dc.contributor.author | DAHIRU MAGAJI ZAREWA | en |
| dc.creator | DAHIRU MAGAJI ZAREWA | en |
| dc.date.accessioned | 2023-09-22T18:04:29Z | |
| dc.date.available | 2023-09-22T18:04:29Z | |
| dc.date.issued | 2009-03-26 | en |
| dc.description.abstract | Comparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paracetamol (15mg) and delay (1 hour) with propantheline (15mg) respectively. Paraetamol concentration was measured in saliva of 8 healthy male, non-smokers and non-alcoholic volunteers. A log data and AUC curves were used to generate pharmacokinetic data and the data obtained compared pharmacokinetically and statistically. On concurrent administration of paracetamol and cimetidine, the pharmacokinetic parameters change where as follows – Cmax decrease by 16%, T1/2ab increase by 2%, Kab increase by 9.0%, T1/2el decrease by 1.9%, Kel decrease by 10%, lag time increase by 11% while the AUC decreases by 19%. On concurrent administration of paracetamol and propantheline the following were observed – decrease in Cmax by 11%, incease in T1/2ab by 1.6%, Kab decrease by 9%, T1/2el increase by 25%, Kel decrease by 17%, lag time increase by 66% while the AUC decrease by 70%. On delayed administration i.e. paracetamol (1g) admistered an hour after the administration of 15mg propantheline there was decrease in Cmax by 45% (P>0.05), increase in T1/2 by 67%, decrease in Kab 31% (P>0.05), | en |
| dc.identifier.uri | https://teras.ng/api/asset/document/a85d8fbd-2234-4594-ab29-05caf50b3597 | en |
| dc.identifier.uri | https://teras.ng/catalog-item/da7a60a6-9acf-4e13-9bab-2ebb6b6ae28f | en |
| dc.identifier.uri | http://dspace.teras-network.net:4000/handle/123456789/40790 | |
| dc.publisher | Ahmadu Bello University Zaria | en |
| dc.title | COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN | en |
| dc.type | Research Theses | en |
| thesis.degree.level | Masters | en |
| thesis.matric.number | MSC/PHARMSCI/57549/2005-2006 | en |