COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN
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Date
2009-03-26
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Ahmadu Bello University Zaria
Abstract
Comparison of the effects of a single oral dose of cimetidine and propantheline
on the pharmacokinetics of paracetamol were studied with paracetamol (1g)
administered alone, concurrently with cimetidine (400mg), delay (1 hour) with
cimetidine (400mg), concurrently with paracetamol (15mg) and delay (1 hour)
with propantheline (15mg) respectively. Paraetamol concentration was measured
in saliva of 8 healthy male, non-smokers and non-alcoholic volunteers. A log data
and AUC curves were used to generate pharmacokinetic data and the data
obtained compared pharmacokinetically and statistically. On concurrent
administration of paracetamol and cimetidine, the pharmacokinetic parameters
change where as follows – Cmax decrease by 16%, T1/2ab increase by 2%, Kab
increase by 9.0%, T1/2el decrease by 1.9%, Kel decrease by 10%, lag time
increase by 11% while the AUC decreases by 19%. On concurrent administration
of paracetamol and propantheline the following were observed – decrease in
Cmax by 11%, incease in T1/2ab by 1.6%, Kab decrease by 9%, T1/2el increase
by 25%, Kel decrease by 17%, lag time increase by 66% while the AUC
decrease by 70%. On delayed administration i.e. paracetamol (1g) admistered an
hour after the administration of 15mg propantheline there was decrease in Cmax
by 45% (P>0.05), increase in T1/2 by 67%, decrease in Kab 31% (P>0.05),